I'm going to go out on a limb here and assume there are XKCD fans reading this. Here's my top 10 favorites;

Velociraptors!
Words that End in GRY
Cat Proximity
The Difference
Floor Tiles
Escalators
Success
Cuttlefish
Tech Support Cheat Sheet
A-Minus-Minus

Though I'm not confident in any / all of them. I still think that the notoriety as ninja turtle vs renaissance artist one needs to be in there somewhere.

Also my list is pretty old, so newer comics weren't in the running.

Which're yours ?


(Edit: actually, this list was the result of weeks of laborious consideration after going through the whole archive, I can sympathize with not producing one on the spot)

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Revisiting Go - Study Journal
My Programming Blog - About the evolution of my go bot.

The trouble with this question is it makes me feel the need to reread the entire archive to check ...

So, I'll come back and edit the thread later when I have, but I know that three of my top ten are:
Tech Support Cheat Sheet (Really works! I mean, seriously, my mother uses it herself and asks me fewer questions, and uses it to help her friends.)
With Apologies to Robert Frost
Complicated (I don't know why, really, but it just tickles me completely.)

I'm just going back to the archive; I may be some time.

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My European rating.

I've got one favorite: Duty Calls.

It describes the stress I get from the Internet pretty well.

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be immersed

Nerd Sniping I'd fall for that.
Substitute My favorite raptor one
A bunch of rocks
Too lazy to go over the archive [again], so some of my favs are probably missing.

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Sanity is for the weak.

The one I always think of (especially when on KGS or forums) is also Duty Calls. Most needed comic ever.

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So you've got an eye?
That don't impress me much

I do really enjoy "A Bunch of Rocks, and "With Apologies to Robert Frost",

Some others I've found quite amusing -

Flow Charts
The Difference

And for some reason I am terribly amused about any of the comics that refer to statistics and everyday life (though that's too many to list here).

One that he did that isn't on the XKCD site to my knowledge, but I thought was hilarious was his comic "1999"

Of course all my friends who were in CS loved the "Ballmer Peak".

I have pasted the link to "Pix Plz" several times while kibbitzing on KGS.

I second Floor Tiles, Cat Proximity and Duty Calls.

A-Minus-Minus sends me into uncontrollable giggles every time I read it.

Secretary Part 3 has precisely one good panel, the one about 9/11 truthers.

Edit #1: Let's add Correlation.

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Occupy Babel!

http://xkcd.com/327/

I've sent this one to a coworker to caution him against passing user input directly to MySQL. Parametrize those queries!

So many awesome comics.

"Oh, yes. Little Bobby Tables, we call him."

And the Nerd Sniping one...actually had a coworker never make it to the punch line of that comic because he got nerd sniped.

Here are a couple favorites of mine, dealing with an awesome programming language:
Python
New Pet

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KGS: schultz [?].

I just love Locke and Demosthenes:

http://xkcd.com/635/

Cheers,
Vesa

sudo make me a sandwich anyone ?

http://xkcd.com/149/

This one is my all time favourite.

Can't believe I forgot about that one. I think I'm with Marcus on this one.

And I don't know how many places this is posted up on the cubicle walls at work.

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KGS: schultz [?].

I forgot about this one: http://xkcd.com/378/

What cracks me up more than the comic is that I can really picture some of my fellow classmates from college talking like this.

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be immersed

Another classic posted on a friends cubicle wall at work.

The thing I really like about xkcd is the mouse overlay text that goes with each of the comics. Often times, that's the funniest part of the joke.

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KGS: schultz [?].

As an equipment tech, this Circuit Diagram was quite entertaining. I sent it to my supervisor and some engineers here at work, and asked them to build me one.

CSam

(Note for people too lazy to click: that's the "real programmers" version of the Four Yorkshiremen sketch.)

On Saturday we had a meeting of the Council of the British Go Association. To all intents and purposes, over lunch we had exactly that conversation. Honestly, no one listening would have worked out we were Go players, they'd just have thought we were computer folk.

Only the last panel, blast it, finished with a vi-trumping instead of an emacs-win, when someone smiled sweetly at me and pointed out that vi users don't get RSI, only emacs users who have to stretch for C- and M- keys. Hrumph.

I can't narrow down my favourite 10 comics. So far I've narrowed it down to my top 50 ...!

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My European rating.

Ah, finally found one my wife likes.

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That which can be destroyed by the truth should be.
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My (sadly neglected, but not forgotten) project: http://dailyjoseki.com

The funniest part for me is usually reading the alt text, like this one: Escalators