White 2 in the first game, facing Black's 4-4 stone has an interesting history in GoGoD. It first appears in game 1 of the Kitani - Go Seigen 10-game match sponsored by Jiji Shinpo when they were still 5-dans (March 1933). Kitani played it of course.

He lost but that did not prevent him from trying it a few more times over the years. Clearly this fuseki was one of those indications of how stubborn he could be. He did not win with it until his eighth try in 1951. In all GoGoD has 13 of his games starting like this with Kitani scoring 3-10! It may have had something to do with who he chose to play it against however. He lost five times against Go Seigen and three times against Sakata, so there were not so many other people involved.
In all GoGoD has 160 games with this beginning. It seems to attract a few players who stick with it. The most recent was the Chinese pro Wang Yang. He tried it in 2003 and then again in 2006, scoring successive wins. Perhaps thinking that he was on to a good thing, he proceeded to lose ten games in a row before giving up on it in 2008.
However, others have done better. Sakata took it up in the early fifties (some time after Kitani scored his first win with it). It looks a little too much like coincidence that Kitani beat Miyashita Shuyo 7p with it in Sept. 1951 and then Sakata used it for the first time in June 1952 to beat the same Miyashita Shuyo. But just in case you have any doubts, Go Seigen used the same fuseki in August 1952 to beat... Miyashita Shuyo! I do not know if it was known as the "Anti-Miyashita" opening in 1950's era fuseki dictionaries. But back to Sakata, he proceeded to win seven in a row, including two against Takagawa and two against Go Seigen (in their 6-game match). Sakata dropped it after a while but returned to it thirty years later in the 1980's. In all he recorded 13 wins against only 5 losses.
Hashimoto Utaro is another well-know proponent during the '50's. He scored 9-7 against a mixed group of players. However, included in his wins was Sakata's sole loss in the 1953 Honinbo league. That tied Sakata with Kitani, who won the playoff to decide the challenger to Takagawa. You can say that this fuseki directly contributed to Takagawa's legendary 9-year run as Honinbo. So you see that regardless of Kajiwara-sensei's opinion, this White 2 hasn't lost every game!
By the way, looking at all 160 examples in GoGoD, no professional player as Black has ever chosen to answer White 2 with a play at the upper left 5-4 point (E16) played by Uberdude. As always YMMV!

Edit: To Bill's point below; Black won 58% of the 160 even games that began this way. In the 50's, however, White did slightly better than Black. I think that probably reflected who was using the opening in the 50's rather than the intrinsic quality of the plays.
Re-edit: Sorry, should have looked at Bill's point more carefully. The diagonal 4-4 formation shown is a 53% winner for Black in all even games in GoGoD (969 games). However, since 2002 (approximately the 6.5 point komi era) it is 53% plus for White. In handicap games (1223 games!) Black won 50% and White won 42%. Note that most of the handicap games in GoGoD are classical games between top players with a large percentage of unfinished/unknown results.
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Dave Sigaty"Short-lived are both the praiser and the praised, and rememberer and the remembered..."
- Marcus Aurelius; Meditations, VIII 21